Hideaki TAGAMI
| Division | Biological Science, Associate Professor |
|---|---|
| Academic Degree | Doctor of Science |
Contents of page
Research Field
Molecular Biology, Chromatin Regulation
Keywords
Chromatin regulation, Histone complexes,
Current Research Topics
The research of this group focuses on chromatin regulation using a strategy of protein complex analysis. We address the molecular mechanisms through functional analyses of the interaction partners of histones in yeast.
The major projects are the following:
The major projects are the following:
- Molecular mechanisms of chromatin assembly
We are studying the histone deposition machinery to understand the molecular events leading to chromatin assembly. - Chromatin regulation on gene expression
We are interested in the connections between histone dynamics and transcription. - Histone metabolism and cell cycle
We investigate the regulations of histone’s life: from the synthesis to degradation, and the molecular link between the regulation and cell cycle progression.
Selected Publications
Purification of Histone Variant-Interacting Chaperone Complexes. Methods in Molecular Biology, 1832, 51-60 (2018)
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres., Cell, 137, 487-497 (2009).
From the view of histone complexes: A sketch of molecular players on the chromatin assembly events. In “DNA Structure, Chromatin and Gene Expression” Transworld Research Network, 57, 145-158 (2006).
Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis, Cell, 116, 51-61 (2004).
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres., Cell, 137, 487-497 (2009).
From the view of histone complexes: A sketch of molecular players on the chromatin assembly events. In “DNA Structure, Chromatin and Gene Expression” Transworld Research Network, 57, 145-158 (2006).
Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis, Cell, 116, 51-61 (2004).
