Molecular Biology and Cellular Physiology of Exercise

skeletal muscle, atherosclerosis, exercise

1. How to prevent against cachectic factor-induced skeletal muscle atrophy:
   Cachectic factor induces skeletal muscle atrophy. Exercise training prevents against skeletal muscle atrophy, however, little is known about the underlying mechanisms. A goal in our lab is to establish the factor “X” to prevent against skeletal muscle atrophy.
   
   
2. Molecular mechanism of prevention against atherosclerosis by exercise:
   Exercise training prevents the development of atherosclerosis. Our goal in this project is to identify and determine the molecular mechanism in exercise-induced protection of endothelial cell damage (dysfunction) in atherosclerosis.

(Orignal Articles)

Regular exercise stimulates endothelium autophagy via IL-1 signaling in ApoE deficient mice. FASEB J, 35:e21698 (2021).

Muscle-derived SDF-1α/CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis. Am J Physiol Regul Integr Comp Physiol, 317:R770-R779.(2019).

p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle. FASEB J, 33:8022-8032 (2019).

Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice. Free Radic Biol Med, 113:212-223 (2017).

ADAM12: a genetic modifier of preclinical peripheral arterial disease. Am J Physiol Heart Circ Physiol, 309:H790-803 (2015).

Enhanced skeletal muscle expression of extracellular superoxide dismutase mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling. Circulation: Heart Failure, 8:188-97 (2015).

Extracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia and exercise intolerance in mice with congestive heart failure.Circulation: Heart Failure, 7:519-30 (2014).

Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes, 63:1605-11 (2014).

Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse. Atherosclerosis, 232:414-9 (2014).

Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Cell Rep, 3:1449-56 (2013).

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J, 27:4184-93 (2013).

Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Medicine, 19:640-5 (2013).

A novel PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell, 151:1319-31 (2012).

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A, 109:6739-44 (2012).

Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy. J Biol Chem, 286:38456-65 (2011).

Cortisol-induced CXCR4 augmentation mobilizes T lymphocytes after acute physical stress. Am J Physiol Regul Integr Comp Physiol, 288:R591-9 (2005).

(Review Articles)

骨格筋の恒常性維持に関する最新知見. 体力科学, 67(3):245-249 (2018).