NAGOYA CITY UNIVERSITY Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences

Research Groups

Medicinal and Life Sciences

Department Research topics
Organic and Medicinal Chemistry

(Hidehiko Nakagawa, Ph.D., Professor)

  • Development of useful organic synthetic reactions for building drug structures.
  • Rational molecular design and synthesis of new medical leads.
  • Structure-activity relationship study of designed and synthesized medical leads
  • Mechanistic study of designed and synthesized bio-functional molecules
  • Chemistry and biology of reactive oxygen species and oxidative stress
Bioorganic-inorganic Chemistry

(Tsunehiko Higuchi, Ph.D., Professor)

  • Chemistry of Synthetic Enzyme Mimics
  • Development and Evaluation of Functional Molecules
  • Rational Design and Synthesis of Potential Pharmaceuticals. Development of Novel Methodology for Drug Discovery
  • Creation of New Concept for the Development of Functional Molecules
Synthetic Organic Chemistry

(Seiichi Nakamura, Ph.D., Professor)

  • Studies on the Synthesis of Biologically Active Natural Products
  • Development of Efficient Methods for Construction of Molecular Architectures
  • Development of Novel Asymmetric Reactions
Synthetic Supramolecular Chemistry

(Shin-ichi Ikeda, Ph.D., Associate Professor)

  • Development of New Organic Reaction Using Transition-Metal Catalysts
  • Analysis of Molecular Recognition by Computational Chemstry
Cellular Biophysics

(Naohide Hirashima, Ph.D., Professor)

  • Mechanism of Exocytosis
  • Analysis of Allergic Responses
  • Mechanism of Neural Development
  • Development of Visualization Methods for Cellular Responses
Physical Chemistry of Colloid and Polymer

(Junpei Yamanaka, Ph.D., Professor)

  • Phase transition and phase separation of colloids
  • Theoretical and numerical study of nonequilibrium soft matter
  • Development of novel photonic colloidal materials
  • Crystallization of charged colloids under microgravity
Structural Biology and Biomolecular Engineering

(Koichi Kato, Ph.D., Professor)

  • Structural Glycobiology
  • Protein Sociology
  • Structural Immunology
  • NMR Structural Biology and Protein X-ray Crystallography
  • Structure-based Biomolecular Engineering
Molecular Biology

(Michiko Shirane, Ph.D., Processor)

  • Neurodegenerative disorders
  • Intracellular trafficking
  • Malignant transformation

  • Epigenetics and gene function
  • Adipocyte differentiation
Drug Delivery and Nano Pharmaceutics

(Tetsuya Ozeki, Ph.D., Professor)

  • DDS for Brain Tumor Therapy
  • Nanoparticles DDS for Inhalation Therapy of Tuberculosis
  • DDS for Regeneration Medication of Bone Tissue
  • DDS for Malaria Therapy
  • Nanoparticles for Water-insoluble Drugs
Pharmaco-MicroRNA Genomics

(Yoichi Fujii, VMD, Ph.D., Associate Professor)

  • microRNA hunting
  • Investigation of function of the microRNA genes
  • Decipherment of the quantum RNA Language (QRL)
  • Development of nucleic acids agents and edible RNA vaccine for human diseases
  • Construction of Open Source Software (OSS) for computing algorithms

Experimental and Clinical Pharmacy

Department Research topics

(Toshiaki Makino, Ph.D., Professor)

  • Clinical and Experimental Pharmacology of Kampo Medicines
  • Molecular & Cellular Biology of Plant Secondary Metabolism
  • Natural Product Chemistry using Endogenous Bacteria
  • Validation of Natural Medicines
Molecular and Cellular Health Sciences

(Shigeaki Hida, Ph.D., Professor)

  • Role of interleukins in immune and inflammatory reactions
  • Host defense mechanism against Mycobacterium tuberculosis
  • Etiological role of cigarette smoking in rheumatoid arthritis
  • Immune evasion mechanisms by microorganisms
Biological Chemistry

(Shin-ichi Hoshino, Ph.D., Professor)

  • Mechanism of mRNA Decay in Eukaryotes
  • Posttranscriptional Regulation of Gene Expression
  • Mechanism of mRNA Quality Control (Surveillance)
  • Roles of eRF3 Family G Proteins in the Regulation of mRNA Decay
Molecular and Cellular Pharmacology

(Yuji Imaizumi, Ph.D., Professor)

  • Molecular Functions of Ion Channels and Related Diseases / Channelopathy
  • Bioimaging of Cellular Ion Dynamics and Ion Channel Molecules
  • Discovery of Drugs acting on Ion Channels and Screening System
Biomedical Science

(Mitsuharu Hattori, Ph.D., Professor)

  • Molecular mechanism of brain development
  • Molecular mechanism of neuronal shape formation
  • Understanding how human brain works
  • Exploring novel lipid signaling in neuronal cells

(Hiroaki Yuasa, Ph.D., Professor)

  • Functions and Regulation Mechanisms of Transporters Involved in Drug Disposition
  • Roles of Transporters in Drug Disposition
  • Physiological and Pathophysiological Roles of Transporters
  • Methodologies of Evaluation and Prediction of Drug Disposition
Molecular, Cellular Pathobiology and Therapeutics

(Mineyoshi Aoyama, Ph.D.,M.D., Professor)

  • Molecular Mechanism of Atherosclerosis
  • Pathobiology of Thrombosis and Development of New Therapeutics
  • Analysis of Pathophysiological Roles of Sphingolipids in the Development of Cardiovascular and Metabolic Syndromes
  • Cellular Mechanism of Wound Healing and Development of New Therapeutics
Cell Signalling

(Hidetoshi Hayashi, Ph.D., Professor)

  • Stressors and Lifestyle Related Disease
  • Cellular Stress and Regulation of Cell Growth, Apoptosis and Differentiation
  • Development of Molecular Target Therapy of Cancer
  • Drug Metabolism in Pathological Conditions
  • Development of Experimental Models to Reconstitute Drug Metabolism and Toxicity in Human

(Kazuhiko Kume, M.D., Ph.D., Professor)

  • Sleep and Circadian rhythm studies using Drosophila melanogaster
  • Establishment of effective treatment of neuropathic pain
  • Prevention and treatment of undesirable effect of the drugs
  • Establishment of effective treatment of metabolic syndrome.
Clinical Pharmacy

(Tadashi Suzuki, Ph.D., Professor)

  • Differentiation of Human iPS Cells into Hepatocytes and Small Intestinal Epithelial Cells
  • Establishment of Gisease Specific iPS Cells from Inherited Metabolic Disease Patients
  • Mechanism of Diabetes Vascular Endothelium Dysfunction
  • Development of Continuing Education Program for Pharmacists
Hospital Pharmacy

(Kazunori Kimura, Ph.D., Professor)

  • aaaa
Regulatory Science

(Masahiro Tohkin, Ph.D., Professor)

  • The molecular mechanism of idiosyncratic adverse drug reactions.
  • The biomarker for idiosyncratic adverse drug reactions, and clinical application for the precision medicine.
  • Ethnic difference of the drug efficacy and safety.
  • Quantitative structure–activity relationship of the toxicity of environmental chemicals and drugs.
  • Pharmaco-epidemiological study of drug safety and efficacy.
  • Meta-analysis of the drug efficacy and safety.

Affiliate Graduate School

Department Research topics

(Masahiro Aoki, M.D., Professor (Division of Molecular Pathology, Aichi Cancer Center))

  • Replication of DNA Tumor Virus and Host Cellular Response
  • Analysis of Viral Proliferation using Genetic Engineered Recombinant Viruses
  • Virotherapy for Cancers
Experimental Gerontology

(Koichi Iijima, Ph. D., Associate Professor (Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia))

  • Mechanisms underlying Alzheimer's disease (AD) pathogenesis
  • Identification of genetic risk factors of AD
  • Development of therapeutic strategy for AD
  • Endocytosis and axonal transport defects in AD
Pharmaceutical Quality Science

(Yukihiro Goda, Ph.D., Professor (Division of Drugs, National Institute of Health Sciences))

Integrative Bioscience

(Motohiro Nishida, Ph.D., Professor (Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences))

Regulatory Science for Evaluation of Pharmaceuticals and Medical Devices

(Masayoshi Shibatsuji, Ph.D., Professor (Pharmaceuticals and Medical Devices Agency))

  • PMDA
  • Pharmaceuticals
  • Anti-cancer drugs
  • Medical devices
  • Approval review

Educational Research Center for Clinical Pharmacy

Department Research topics
Clinical Pharmacy

(Tadashi Suzuki, Ph.D., Professor)

  • Differentiation of Human iPS Cells into Hepatocytes and Small Intestinal Epithelial Cells
  • Establishment of Gisease Specific iPS Cells from Inherited Metabolic Disease Patients
  • Mechanism of Diabetes Vascular Endothelium Dysfunction
  • Development of Continuing Education Program for Pharmacists