NAGOYA CITY UNIVERSITY Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences

Research Groups

Medicinal and Life Sciences

Department Research topics
Organic and Medicinal Chemistry

(Hidehiko Nakagawa, Ph.D., Professor)

  • Molecular design, synthesis, and evaluation of biologically functional and useful compounds
  • Development of the methods for exploration and analysis for bioactive substances like medical leads based on chemical approach
  • Bioorganic chemistry for reactive oxygen species and nitric oxide
  • Development of the compounds for controlling cellular properties based on photochemistry and organic chemistry
Bioorganic-inorganic Chemistry

(Tsunehiko Higuchi, Ph.D., Professor)

  • Chemistry of Synthetic Enzyme Mimics
  • Development and Evaluation of Functional Molecules
  • Rational Design and Synthesis of Potential Pharmaceuticals. Development of Novel Methodology for Drug Discovery
  • Creation of New Concept for the Development of Functional Molecules
Synthetic Organic Chemistry

(Seiichi Nakamura, Ph.D., Professor)

  • Studies on the Synthesis of Biologically Active Natural Products
  • Development of Efficient Methods for Construction of Molecular Architectures
  • Development of Novel Asymmetric Reactions
Synthetic Supramolecular Chemistry

(Shin-ichi Ikeda, Ph.D., Associate Professor)

  • Development of New Organic Reaction Using Transition-Metal Catalysts
  • Analysis of Molecular Recognition by Computational Chemstry
Cellular Biophysics

(Naohide Hirashima, Ph.D., Professor)

  • Mechanism of Exocytosis
  • Analysis of Allergic Responses
  • Mechanism of Neural Development
  • Development of Visualization Methods for Cellular Responses
Physical Chemistry of Colloid and Polymer

(Junpei Yamanaka, Ph.D., Professor)

  • Phase transition and phase separation of colloids
  • Theoretical and numerical study of nonequilibrium soft matter
  • Development of novel photonic colloidal materials
  • Crystallization of charged colloids under microgravity
Molecular Biology

(Michiko Shirane, Ph.D., Processor)

  • Neurodegenerative disorders
  • Intracellular trafficking
  • Malignant transformation

  • Epigenetics and gene function
  • Adipocyte differentiation
Drug Delivery and Nano Pharmaceutics

(Tetsuya Ozeki, Ph.D., Professor)

  • DDS for Brain Tumor Therapy
  • Nanoparticles DDS for Inhalation Therapy of Tuberculosis
  • DDS for Regeneration Medication of Bone Tissue
  • DDS for Malaria Therapy
  • Nanoparticles for Water-insoluble Drugs
Pharmaco-MicroRNA Genomics

(Yoichi Fujii, VMD, Ph.D., Associate Professor)

  • microRNA hunting
  • Investigation of function of the microRNA genes
  • Decipherment of the quantum RNA Language (QRL)
  • Development of nucleic acids agents and edible RNA vaccine for human diseases
  • Construction of Open Source Software (OSS) for computing algorithms
Structural Biology and Biomolecular Engineering

(Koichi Kato, Ph.D., Professor)

  • Structural Glycobiology
  • Protein Sociology
  • Structural Immunology
  • NMR Structural Biology and Protein X-ray Crystallography
  • Structure-based Biomolecular Engineering

Experimental and Clinical Pharmacy

Department Research topics
Pharmacognosy

(Toshiaki Makino, Ph.D., Professor)

  • Clinical and Experimental Pharmacology of Kampo Medicines
  • Molecular & Cellular Biology of Plant Secondary Metabolism
  • Natural Product Chemistry using Endogenous Bacteria
  • Validation of Natural Medicines
Molecular and Cellular Health Sciences

(Shigeaki Hida, Ph.D., Professor)

  • Role of interleukins in immune and inflammatory reactions
  • Host defense mechanism against Mycobacterium tuberculosis
  • Etiological role of cigarette smoking in rheumatoid arthritis
  • Immune evasion mechanisms by microorganisms
Biological Chemistry

(Shin-ichi Hoshino, Ph.D., Professor)

  • Mechanism of mRNA Decay in Eukaryotes
  • Posttranscriptional Regulation of Gene Expression
  • Mechanism of mRNA Quality Control (Surveillance)
  • Roles of eRF3 Family G Proteins in the Regulation of mRNA Decay
Molecular and Cellular Pharmacology

(Hisao Yamamura, Ph.D., Professor)

  • Molecular Functions of Ion Channels and Related Diseases / Channelopathy
  • Bioimaging of Cellular Ion Dynamics and Ion Channel Molecules
  • Discovery of Drugs acting on Ion Channels and Screening System
Biomedical Science

(Mitsuharu Hattori, Ph.D., Professor)

  • Molecular mechanism of brain development
  • Molecular mechanism of neuronal shape formation
  • Understanding how human brain works
  • Exploring novel lipid signaling in neuronal cells
Biopharmaceutics

(Hiroaki Yuasa, Ph.D., Professor)

  • Functions and Regulation Mechanisms of Transporters Involved in Drug Disposition
  • Roles of Transporters in Drug Disposition
  • Physiological and Pathophysiological Roles of Transporters
  • Methodologies of Evaluation and Prediction of Drug Disposition
Molecular, Cellular Pathobiology and Therapeutics

(Mineyoshi Aoyama, Ph.D.,M.D., Professor)

  • Molecular Mechanism of Atherosclerosis
  • Pathobiology of Thrombosis and Development of New Therapeutics
  • Analysis of Pathophysiological Roles of Sphingolipids in the Development of Cardiovascular and Metabolic Syndromes
  • Cellular Mechanism of Wound Healing and Development of New Therapeutics
Cell Signalling

(Hidetoshi Hayashi, Ph.D., Professor)

  • Stressors and Lifestyle Related Disease
  • Cellular Stress and Regulation of Cell Growth, Apoptosis and Differentiation
  • Development of Molecular Target Therapy of Cancer
  • Drug Metabolism in Pathological Conditions
  • Development of Experimental Models to Reconstitute Drug Metabolism and Toxicity in Human
Neuropharmacology

(Kazuhiko Kume, M.D., Ph.D., Professor)

  • Sleep and Circadian rhythm studies using Drosophila melanogaster
  • Establishment of effective treatment of neuropathic pain
  • Prevention and treatment of undesirable effect of the drugs
  • Establishment of effective treatment of metabolic syndrome.
Clinical Pharmacy

(Tadashi Suzuki, Ph.D., Professor)

  • Differentiation of Human iPS Cells into Hepatocytes and Small Intestinal Epithelial Cells
  • Establishment of Gisease Specific iPS Cells from Inherited Metabolic Disease Patients
  • Mechanism of Diabetes Vascular Endothelium Dysfunction
  • Development of Continuing Education Program for Pharmacists
Hospital Pharmacy

(Kazunori Kimura, Ph.D., Professor)

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Regulatory Science

(Masahiro Tohkin, Ph.D., Professor)

  • The molecular mechanism of idiosyncratic adverse drug reactions.
  • The biomarker for idiosyncratic adverse drug reactions, and clinical application for the precision medicine.
  • Ethnic difference of the drug efficacy and safety.
  • Quantitative structure–activity relationship of the toxicity of environmental chemicals and drugs.
  • Pharmaco-epidemiological study of drug safety and efficacy.
  • Meta-analysis of the drug efficacy and safety.

Affiliate Graduate School

Department Research topics
Oncology

(Masahiro Aoki, M.D., Professor (Division of Molecular Pathology, Aichi Cancer Center))

  • Replication of DNA Tumor Virus and Host Cellular Response
  • Analysis of Viral Proliferation using Genetic Engineered Recombinant Viruses
  • Virotherapy for Cancers
Experimental Gerontology

(Koichi Iijima, Ph. D., Associate Professor (Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia))

  • Mechanisms underlying Alzheimer's disease (AD) pathogenesis
  • Identification of genetic risk factors of AD
  • Development of therapeutic strategy for AD
  • Endocytosis and axonal transport defects in AD
Pharmaceutical Quality Science

(Yoji Sato, Ph.D., Professor (Division of Cell-Based Therapeutic Products, National Institute of Health Sciences))

Integrative Bioscience

(Motohiro Nishida, Ph.D., Professor (Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences))

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Regulatory Science for Evaluation of Pharmaceuticals and Medical Devices

(Masayoshi Shibatsuji, Ph.D., Professor (Pharmaceuticals and Medical Devices Agency))

  • PMDA
  • Pharmaceuticals
  • Anti-cancer drugs
  • Medical devices
  • Approval review

Educational Research Center for Clinical Pharmacy

Department Research topics
Clinical Pharmacy

(Tadashi Suzuki, Ph.D., Professor)

  • Differentiation of Human iPS Cells into Hepatocytes and Small Intestinal Epithelial Cells
  • Establishment of Gisease Specific iPS Cells from Inherited Metabolic Disease Patients
  • Mechanism of Diabetes Vascular Endothelium Dysfunction
  • Development of Continuing Education Program for Pharmacists