StaffsTadashi Suzuki, Ph.D., Professor
Tamihide Matsunaga, Ph.D., Professor
Takahiro Iwao, Ph.D., Associate Professor
Chigusa Kikuchi, Ph.D., Assistant Professor
Tadahiro Hashita, Ph.D., Assistant Professor
- Differentiation of Human iPS Cells into Hepatocytes and Small Intestinal Epithelial Cells
- Establishment of Gisease Specific iPS Cells from Inherited Metabolic Disease Patients
- Mechanism of Diabetes Vascular Endothelium Dysfunction
- Development of Continuing Education Program for Pharmacists
- Induced pluripotent stem (iPS) cells are capable of differentiating into three embryonic germ layers and germ cells. The cells apparently differentiate into various types of mature cells, and are thereby an attractive source for routine access to large numbers of cells that can be used for the development of candidate drug-screening strategies replacing primary cells. We investigated the differentiation methods of human iPS cells into hepatocytes and small intestinal epitherial cells useful for pharmacokinetic and toxicokinetic examinations such as induction of drug metabolism enzymes and interactions of candidate drugs with drugs or biological macromolecules.
- Glycogen storage disease (GSD) type Ib is an autosomal recessive disorder caused by a deficiency in microsomal glucose 6-phosphate translocase. The pathogenesis of this disease is poorly understood. We establish the disease specific iPS cells from GSD type Ib patients to clarify the pathogenic mechanisms.
- We study diabetes vascular endothelium dysfunction from not only diabetes model animal data, but also clinical data.
- This center supports 6-year pharmacy education program and the continuing education of pharmacists who work in medical scenes. We also study education of clinical pharmacy by means of simulation of medication.
(1)Human ES Cells / Human iPS Cells
(2)Diabetes Rat Model / Thickening Mesenteric Artery of Diabetes Rat Model
(3) Development of new training methods of pharmacists: In order to support new 6-year pharmacy education program, we research and develop training methods of useful pharmacy education in medical scenes. We carry out the new methods in the clinical pharmacy training and study the education effect.
Graduate School of Pharmaceutical Sciences, Nagoya City University,
3-1, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan