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【Research News】Adverse pregnancy and perinatal outcome in patients with recurrent pregnancy loss: Multiple imputation analyses with propensity score adjustment applied to a large-scale birth cohort of the Japan Environment and Children's Study

January 22,2019

"Japan Environment and Children's Study (JECS)" planned by the Ministry of the Environment, Government of Japan, consisted of 104102 registered pregnancies recruited during the first 3 years of the JECS, and their babies are now being followed up for 13 years mainly to examine the influence of the uterine environment on the fetus. Nagoya City University has conducted the JECS since 2010.

We investigated the relation between adverse pregnancy and recurrent miscarriage. Results showed no increased risk of a congenital anomaly, aneuploidy, neonatal asphyxia, or a small for date infant was observed among the children from women with a history of recurrent pregnancy loss. A novel increased risk of placental adhesion and uterine infection was found. In addition, the birth rate of male infant decreased in patients of recurrent miscarriage.

This study, especially the finding that there was no increased risk of a live birth with a congenital anomaly or aneuploidy in women with a history of recurrent pregnancy loss as compared to women with no history of pregnancy loss, could encourage women who might hesitate to attempt a subsequent pregnancy.

Published online Date

December 15,2018

Journal

American Journal of Reproductive Immunology

Title Adverse pregnancy and perinatal outcome in patients with recurrent pregnancy loss: Multiple imputation analyses with propensity score adjustment applied to a large-scale birth cohort of the Japan Environment and Children’s Study

Author Mayumi Sugiura‐Ogasawara, Takeshi Ebara, Yasuyuki Yamada, Naoto Shoji, Taro Matsuki, Hirohisa Kano, Takahiro Kurihara, Toyonori Omori, Motohiro Tomizawa, Maiko Miyata, Michihiro Kamijima, Shinji Saitoh, and The Japan Environment Children's Study (JECS) Group
Article URL https://doi.org/10.1111/aji.13072
Researcher URL

http://www.med.nagoya-cu.ac.jp/obgyne.dir/e_outline.html

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