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【Research News】Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice

November 16,2017

Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria such as Porphyromonas gingivalis (P. gingivalis). It has been suggested that periodontitis may contribute to the onset and the progression of Alzheimer's disease (AD). However, it has not been clear for the causative relationship between periodontitis and AD. In the present study, we investigated whether periodontitis induced by P. gingivalis modulates the pathological features of AD using a transgenic mouse model of AD (APP-Tg mouse). Cognitive function was significantly impaired in APP-Tg mice with periodontitis, compared to that in control APP-Tg mice. The levels of amyloid β (Aβ) deposition, levels of Aβ40, and Aβ42 in both the hippocampus and cortex were higher in APP-Tg mice with periodontitis than in control mice. The levels of IL-1β , TNF-α, and LPS in the brain were higher in inoculated mice than in control mice. These lines of evidence suggest that periodontitis evoked by P. gingivalis may exacerbate brain Aβ deposition, leading to enhanced cognitive impairments, by a mechanism that involves triggering brain inflammation, and that oral care and treatment of periodontitis may prevent the development and progression of AD.

Published Online Date :6 July, 2017

Journal:npj Aging and Mechanisms of Disease

Title Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice
Author Naoyuki Ishida, Yuichi Ishihara, Kazuto Ishida, Hiroyuki Tada, Yoshiko Funaki-Kato, Makoto Hagiwara, Taslima Ferdous, Mohammad Abdullah, Akio Mitani, Makoto Michikawa, Kenji Matsushita
Article URL https://www.nature.com/articles/s41514-017-0015-x
Researcher URL

http://www.med.nagoya-cu.ac.jp/1seika.dir/biochem1home.htm

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